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Title:: Efficacy Evaluation of Argatroban in Treatment of Lower Extremity Deep Vein Thrombosis

稿件编号:: 201007012

作者:: 张天华; 姜维良; 张英男; 哈尔滨医科大学附属第二医院血管外科（哈尔滨 150086）

Author(s):: -

关键词:: ; 阿加曲班; 肝素; 深静脉血栓形成; 治疗; 血小板减少症

Keywords:: -

分类号:: R654.4

DOI:: -

文献标识码:: B

摘要:: 目的    比较常规使用肝素和阿加曲班治疗下肢深静脉血栓（DVT）患者的临床疗效。
方法    将188例下肢DVT患者按照随机数字表分成阿加曲班组（n=94）和对照组（低分子肝素钙+尿激酶，n=94），比较2组患者治疗前、后双侧肢体周径差和疗效的差异，并在治疗过程中监测凝血指标（PT、APTT及PLT）变化。
结果    阿加曲班组治疗10 d后，双侧肢体周径差较治疗前明显减小（P<0.05），总有效率（97.87%）优于对照组（89.37%），P<0.05。阿加曲班组无血小板减少症（HIT）发生，对照组发生2例HIT；阿加曲班组PT、APTT和PLT变化均处于正常范围，与对照组比较差异无统计学意义（P>0.05）。
结论   阿加曲班治疗下肢DVT安全、有效。

Abstract:

参考文献/References

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《中国普外基础与临床杂志》[ISSN:1007-9424/CN:51-1505/R]

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