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白介素、C-反应蛋白和纤维蛋白原在下肢深静脉血栓炎症反应中的作用(PDF)

《中国普外基础与临床杂志》[ISSN:1007-9424/CN:51-1505/R]

期数:
2010年07期
页码:
660-663
栏目:
专题
出版日期:
2010-07-22

文章信息/Info

Title:
Role of Interleukin, C-Reactive Protein, and Fibrinogen in Inflammatory Response of Lower Limbs Deep Vein Thrombosis
稿件编号:
201007006
作者:
刘晓毅1; 杨林2; 祁光裕1; 车向明1
1.西安交通大学医学院第一附属医院普外科(西安 710061); 2.复旦大学附属华山医院普外科（上海 200040）
Author(s):
LIU Xiao-yi 1;  YANG Lin 2;  QI Guang-yu 1;  CHE Xiang-ming 1.
 1.Department of General Surgery, The First Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an 710061, China; 2.Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
关键词:
下肢深静脉血栓;  炎症因子;  白介素;  C-反应蛋白;  纤维蛋白原
Keywords:
-
分类号:
R543.6
DOI:
-
文献标识码:
A
摘要:
目的 探讨炎症因子血清白介素-6（IL-6）、白介素-10（IL-10）、C-反应蛋白（CRP）和纤维蛋白原（FIB）在下肢深静脉血栓形成（deep vein thrombosis，DVT）中的作用。
方法 30例DVT患者为DVT组，30例健康自愿者为正常对照组，检测DVT组患者治疗前、后及正常对照组血清IL-6、IL-10、CRP及FIB浓度。
结果 DVT组患者治疗前血清IL-6、IL-10、CRP和FIB浓度均明显高于正常对照组（P<0.001）; 治疗后DVT组患者血清IL-6、CRP和FIB浓度显著低于治疗前（P<0.001），而血清IL-10浓度则高于治疗前（P<0.001）； 治疗后DVT组患者血清FIB浓度与正常对照组比较差异无统计学意义（P>0.05），血清IL-6、IL-10及CRP浓度仍高于正常对照组（P<0.05）。
结论  炎症因子参与下肢DVT的发生、发展，其中IL-6、CRP及FIB可能在血栓急性期起重要作用，而IL-10 则可能起抗炎作用。
Abstract:
Objective  To study the effect of interleukin-6,10 (IL-6,10), C-reactive protein (CRP), and fibrinogen (FIB) on inflammatory response of lower limbs deep vein thrombosis (DVT).
Methods  Thirty patients with acute lower limb DVT (DVT group) and 30 volunteers (normal control group) were included in this study, and then the concentrations of serum IL-6, IL-10, CRP, and FIB were detected.
Results   The concentrations of serum IL-6, IL-10, CRP, and FIB of patients in DVT group before treatment were higher than those in normal control group (P<0.001). Compared with before treatment, the concentrations of serum IL-6, CRP, and FIB of patients after treatment were lower in DVT group (P<0.001), however, the concentration of serum IL-10 was higher (P<0.001). There was no difference of the concentrations of serum FIB between DVT group after treatment and normal control group (P>0.05), but the concentrations of serum IL-6, IL-10, and CRP of patients in DVT group after treatment were higher than those in normal control group (P<0.05). Conclusion    Inflammatory factors may involve in DVT. Therein IL-6, CRP, and FIB play important roles in acute stage of DVT, and IL-10 may have an anti-inflammatory effect.

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备注/Memo

备注/Memo:
 【通讯作者】刘晓毅，E-mail: jdxy6421@163.com
【作者简介】刘晓毅（1964年-），男，陕西省西安市人，本科，主治医师，主要研究方向为胃肠道肿瘤及血管外科。
更新日期/Last Update: 2010-07-27